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RegisterStripping dose (WinNonlin) [Software]
posted by Helmut 
– Vienna, Austria, 2008-06-30 15:49 (6156 d 06:53 ago) – Posting: # 1987
Views: 12,200
Dear Ravi,
From p 516 of the User's Guide:
Dose associated with initial parameter estimates for macro constant models. In these models, which can be written as a sum of exponentials, dose does not appear explicitly in the model. Rather, the macro constants are a function of dose. Thus, when fitting macro constant models with user-specified initial estimates, the user must specify the associated dose. For single dose macro constant models, when WinNonlin determines initial parameter estimates by curve stripping, the stripping dose is identical to the administered dose.
It's further explained in pp 502-503 of the User's Guide.
It's simply the dose administered.
No. A dose is a dose is a dose.
❝ Now My Question is what this stripping dose is? what does it mean.
From p 516 of the User's Guide:
Dose associated with initial parameter estimates for macro constant models. In these models, which can be written as a sum of exponentials, dose does not appear explicitly in the model. Rather, the macro constants are a function of dose. Thus, when fitting macro constant models with user-specified initial estimates, the user must specify the associated dose. For single dose macro constant models, when WinNonlin determines initial parameter estimates by curve stripping, the stripping dose is identical to the administered dose.
It's further explained in pp 502-503 of the User's Guide.
❝ how one should define its value.
It's simply the dose administered.
❝ Is it drug specific.
No. A dose is a dose is a dose.
(interpreting Gertrude Stein)
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- PK Modelling Ravi 2008-06-30 12:09
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Stripping dose (WinNonlin)Helmut 2008-06-30 13:49
Ing. Helmut Schütz