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dear ravi !
on assumption of (a) linear pharmacoinetics and (b) that absorption and clearance are identical for each dose interval you can predict drug concentrations on multiple dosing using the principle of superposition (refer to appendix E of Gibaldi and Perrier reference) without assuming a specific pharmacokinetic model.
best regards
martin
on assumption of (a) linear pharmacoinetics and (b) that absorption and clearance are identical for each dose interval you can predict drug concentrations on multiple dosing using the principle of superposition (refer to appendix E of Gibaldi and Perrier reference) without assuming a specific pharmacokinetic model.
best regards
martin
Complete thread:
- Single dose animal study Ravi 2008-06-03 10:07
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- Single dose animal studymartin 2008-06-03 16:33
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