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RegisterWinNonlin: steady state setup [Software]
Dear Helmut,
Thank you for your response. Your simulation and explanation makes complete sense to me. However, I am still curious about calculation of CL and MRT. As CL=Dose/AUC and MRT=(AUMC/AUC) - (Duration of Infusion/2). These parameters are dependent on AUC & AUMC. And the problem with AUC & AUMC I see is that baseline being 10, the calculated AUC is sum of exposure due to second dose + exposure due to the baseline concentration of drug already present, which can contribute to as high as 10% of total AUC (200 at Cmax, 10 at 0h). In this situation do you think these parameters (CL and MRT) will still be good representative of Plasma PK for this drug? or there is way to analyze it better?
Thanks again to you and Mittyri for links.
Bob
Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Helmut]
Thank you for your response. Your simulation and explanation makes complete sense to me. However, I am still curious about calculation of CL and MRT. As CL=Dose/AUC and MRT=(AUMC/AUC) - (Duration of Infusion/2). These parameters are dependent on AUC & AUMC. And the problem with AUC & AUMC I see is that baseline being 10, the calculated AUC is sum of exposure due to second dose + exposure due to the baseline concentration of drug already present, which can contribute to as high as 10% of total AUC (200 at Cmax, 10 at 0h). In this situation do you think these parameters (CL and MRT) will still be good representative of Plasma PK for this drug? or there is way to analyze it better?
Thanks again to you and Mittyri for links.
Bob
Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Helmut]
Complete thread:
- WinNonlin: NCA of multiple dosing plasma PK profile bobmarlo 2017-01-15 17:22
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- WinNonlin: steady state setup Helmut 2017-01-16 13:15
- WinNonlin: steady state setup BE-proff 2017-01-17 07:54
- Accumulation Helmut 2017-01-18 02:22
- WinNonlin: steady state setupbobmarlo 2017-01-17 20:36
- NCA agrees with PK-modeling Helmut 2017-01-18 01:41
- NCA agrees with PK-modeling bobmarlo 2017-01-18 05:06
- Winnonlin AUMC_TAU and others mittyri 2017-01-18 18:00
- NCA agrees with PK-modeling Helmut 2017-01-18 01:41
- WinNonlin: steady state setup BE-proff 2017-01-17 07:54
- WinNonlin: NCA of multiple dosing plasma PK profile mittyri 2017-01-16 17:29
- WinNonlin: steady state setup Helmut 2017-01-16 13:15
Ing. Helmut Schütz