Bioequivalence and Bioavailability Forum

WinNonlin: steady state setup [Software]

posted by BE-proff – 2017-01-17 08:54 (3425 d 00:01 ago) – Posting: # 16960
Views: 14,537

Hi Helmut,

❝ Most people are happy with 5×t_½ (96.88% of steady state) whilst others are more strict (7×t_½ 98.44%, 10×t_½ 99.38%

Did you get this information from literature or these figures are your own observations?

One more question - how would you check if steady state has been reached?

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Edit: Standard quotes restored; see also this post #8. [Helmut]

Complete thread:

• WinNonlin: NCA of multiple dosing plasma PK profile bobmarlo 2017-01-15 17:22 
  • WinNonlin: steady state setup Helmut 2017-01-16 13:15
    • WinNonlin: steady state setupBE-proff 2017-01-17 07:54
      • Accumulation Helmut 2017-01-18 02:22
    • WinNonlin: steady state setup bobmarlo 2017-01-17 20:36
      • NCA agrees with PK-modeling Helmut 2017-01-18 01:41
        • NCA agrees with PK-modeling bobmarlo 2017-01-18 05:06
        • Winnonlin AUMC_TAU and others mittyri 2017-01-18 18:00
  • WinNonlin: NCA of multiple dosing plasma PK profile mittyri 2017-01-16 17:29