Bioequivalence and Bioavailability Forum • Emax and ED50: NLME

Emax and ED50: NLME [Software]

posted by gcpatel126 – India, 2015-12-30 16:19 (3399 d 20:25 ago) – Posting: # 15782
Views: 17,908

Hi Helmut,

As we all know, for most of the cases we are validating our methods and software tools based on regulatory's guideline data. The same we are doing for this ED50 calculation. We tried many tools but none of them match exactly or come too closer to guideline data result.

You have written that model is wrong, which model are you talking ? Is it mentioned in guideline ? OR any other ?

You have compared the results and there is difference also, our question is also the same if values are different compare to guideline than is it acceptable to use that tool ?

Finally do you have any preference for software to use for this calculation ?

Many thanks,
Dr. G C Patel

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Complete thread:

Emax and ED50: NLME gcpatel126 2015-12-09 18:08
- Emax and ED50: NLME Helmut 2015-12-10 02:09
  - Emax and ED50: NLME gcpatel126 2015-12-10 17:34
    - Emax and ED50: NLME SDavis 2015-12-15 11:50
      - Emax and ED50: NLME gcpatel126 2015-12-29 15:49
        
        Emax and ED50: NLME Helmut 2015-12-29 17:46
        
        Emax and ED50: NLME gcpatel126 2015-12-29 18:04
        
        Emax and ED50: NLME Helmut 2015-12-29 19:36
        
        Emax and ED50: NLME gcpatel126 2015-12-30 14:43
        
        Emax and ED50: NLME Helmut 2015-12-30 14:56
        
        Emax and ED50: NLMEgcpatel126 2015-12-30 15:19
        
        Validation? Helmut 2015-12-30 16:02
        
        Validation? gcpatel126 2015-12-30 17:47
        
        Validation? Helmut 2015-12-30 21:15
        
        Validation? gcpatel126 2015-12-31 07:06
        
        Validation? gcpatel126 2016-01-11 14:54
        
        EOD Helmut 2016-01-11 22:13