Bioequivalence and Bioavailability Forum • Emax and ED50: NLME

Emax and ED50: NLME [Software]

posted by Helmut – Vienna, Austria, 2015-12-10 03:09 (3838 d 08:15 ago) – Posting: # 15713
Views: 22,071

Hi G.C.,

please RTFM – the “Phoenix NLME 1.3 User’s Guide” in particular. See the two examples pp183–9 (pp191–7 of the PDF). Alternatively you can use one of WNL’s PD models (#101–108): In the Structure-tab Set WNL . Try it with the emax-dataset (Population fitting, default setup):

model run option EC50 Emax NLME Emax Naive pooled 49.4242 101.383 FOCE ELS 49.3846 100.905 WNL 101 Naive pooled 49.4242 101.383 FOCE ELS 49.3846 100.905

Here estimates are identical (generally they are at least very close). However, I prefer the genuine NLME-model (maximum likelihood instead of least squares). Use naïve pooling or FO only to get initial estimates (they are biased). Carry them over as starting values to one of the other engines.

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If you have difficulties with the setup, I suggest to register at Certara’s forum. There you could upload your project-file for examination by people who get paid for that. :-D

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Complete thread:

Emax and ED50: NLME gcpatel126 2015-12-09 18:08
- Emax and ED50: NLMEHelmut 2015-12-10 02:09
  - Emax and ED50: NLME gcpatel126 2015-12-10 17:34
    - Emax and ED50: NLME SDavis 2015-12-15 11:50
      - Emax and ED50: NLME gcpatel126 2015-12-29 15:49
        
        Emax and ED50: NLME Helmut 2015-12-29 17:46
        
        Emax and ED50: NLME gcpatel126 2015-12-29 18:04
        
        Emax and ED50: NLME Helmut 2015-12-29 19:36
        
        Emax and ED50: NLME gcpatel126 2015-12-30 14:43
        
        Emax and ED50: NLME Helmut 2015-12-30 14:56
        
        Emax and ED50: NLME gcpatel126 2015-12-30 15:19
        
        Validation? Helmut 2015-12-30 16:02
        
        Validation? gcpatel126 2015-12-30 17:47
        
        Validation? Helmut 2015-12-30 21:15
        
        Validation? gcpatel126 2015-12-31 07:06
        
        Validation? gcpatel126 2016-01-11 14:54
        
        EOD Helmut 2016-01-11 22:13