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RegisterEstimated Cτss [Software]
posted by Helmut 
– Vienna, Austria, 2015-02-18 13:48 (3715 d 18:05 ago) – Posting: # 14456
Views: 4,925
Hi MMW,
If you have reliable estimates (≥3 data points) of λz, yes. See this presentation (slides 16–19). Easy to implement the formula(s) with a few custom transformations In PHX/WNL. Does not only help to correct for deviations from the planned sampling schedule but also – more importantly – to deal with missing values.
I would do so only as a last resort if the option above is not possible.
❝ Could we calculate the pk parameter Cτss in Phoenix WinNonlin version 6.3?
If you have reliable estimates (≥3 data points) of λz, yes. See this presentation (slides 16–19). Easy to implement the formula(s) with a few custom transformations In PHX/WNL. Does not only help to correct for deviations from the planned sampling schedule but also – more importantly – to deal with missing values.
❝ Could we use Clast = Cτss; as Clast is available in current version software?
I would do so only as a last resort if the option above is not possible.
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- Cτss in Phoenix/WinNonlin 6.3 mmw 2015-02-18 10:10
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Estimated CτssHelmut 2015-02-18 12:48
- Estimated Cτss mmw 2015-02-19 05:35
- Estimated CτssHelmut 2015-02-18 12:48
Ing. Helmut Schütz