Bioequivalence and Bioavailability Forum

Hi Samaya,

❝ I was performing IVIVC using IVIVC Wizard…

I only know the IVIVC Toolkit. Which version of Phoenix/WinNonlin are you working with?

❝ It would be very helpful if anyone can explain exact meaning of following correlation models…

1. The same time-scale in vitro and in vivo is used. I never have seen an example in the “real world”. Maybe that’s the reason why you didn’t mention it.
   
2. Time scaling of in vivo part. Most commonly applied model.
   
3. Like #2 but modeling a lag-time in vivo.
   
4. Like #3 but with an intercept.

❝ … and which correlation model is to be chosen while performing IVIVC?

It is your job to find out (and validate) which model fits your data best. The IVIVC Toolkit provides an entire arsenal of methods doing so.
If you are not sure, consider registering at Pharsight’s Extranet, where you could upload your pro­ject-file for further exploration.