Bioequivalence and Bioavailability Forum • Use nominal times

Use nominal times [Software]

posted by Beholder – Russia, 2014-04-02 10:23 (4461 d 05:26 ago) – Posting: # 12754
Views: 12,642

Dear Fabrice,

❝ For instance, if you are sampling in a phase with an apparent half-life of 8 h: taking a sample 10% before the planned time will result in a bias of less than 1%… no real concern here :cool: !

❝ However, if you are in a phase with an apparent half-life of 15 min (quick distribution phase for instance), taking a sample 10% too early would result in a bias > 30%… more difficult to justify keeping the concentration in descriptive statistics :lookaround: .

Could you please clarify how did you calculate the bias for first (<1%) and second (>30%) example?

—
Best regards
Beholder

Complete thread:

WNL, time deviations Beholder 2014-03-25 06:23
- Use nominal times fno 2014-03-25 09:47
  - Use nominal times Beholder 2014-03-27 07:50
    - Data binning Helmut 2014-03-27 13:47
      - Data binning Beholder 2014-03-28 08:08
      - Mean concentration curves – which mean #666 d_labes 2014-03-28 11:30
  - Use nominal times AngusMcLean 2014-03-29 13:06
    - Use nominal times mittyri 2014-03-29 14:45
  - Use nominal times mittyri 2014-03-31 20:31
    - Use nominal times fno 2014-04-01 17:48
      - Use nominal timesBeholder 2014-04-02 08:23
        
        Use nominal times fno 2014-04-02 17:16
      - SOPitis? Helmut 2014-04-02 11:57
        
        SOPitis? fno 2014-04-04 09:49
- WNL, time deviations SDavis 2014-04-24 15:10