Bioequivalence and Bioavailability Forum • Use nominal times

Use nominal times [Software]

posted by Beholder – Russia, 2014-03-27 08:50 (4467 d 04:11 ago) – Posting: # 12722
Views: 12,933

Dear Fno,

❝ Descriptive statistics at the concentration level, and therefore average graphs, should be based on nominal sampling times, not on actual ones.

Applying this approach the graphs will not reflect the real PK profiles. In terms of time-concentration matching.

❝ IMHO, such a rule can exclude a point with a too large time deviation from descriptive statistics (but not from the calculation of PK parameters).

What about little deviations? 1-3 min, for example. Either little or big deviations, anyway according to this approach we need to use nominal time in order to eliminate the points from this graph...

I thought just that there would be any special tool in WNL for accounting time deviations that would also allow us to make ordinary graphs. I mean without additional points which were caused by time deviations.

—
Best regards
Beholder

Complete thread:

WNL, time deviations Beholder 2014-03-25 06:23
- Use nominal times fno 2014-03-25 09:47
  - Use nominal timesBeholder 2014-03-27 07:50
    - Data binning Helmut 2014-03-27 13:47
      - Data binning Beholder 2014-03-28 08:08
      - Mean concentration curves – which mean #666 d_labes 2014-03-28 11:30
  - Use nominal times AngusMcLean 2014-03-29 13:06
    - Use nominal times mittyri 2014-03-29 14:45
  - Use nominal times mittyri 2014-03-31 20:31
    - Use nominal times fno 2014-04-01 17:48
      - Use nominal times Beholder 2014-04-02 08:23
        
        Use nominal times fno 2014-04-02 17:16
      - SOPitis? Helmut 2014-04-02 11:57
        
        SOPitis? fno 2014-04-04 09:49
- WNL, time deviations SDavis 2014-04-24 15:10