Bioequivalence and Bioavailability Forum

Crap² [Software]

posted by Helmut  – Vienna, Austria, 2014-02-11 14:45 (4511 d 20:01 ago) – Posting: # 12397
Views: 9,208

Hi John,

❝ More or less it will be a bioanalytical nightmare since the pooled concentration will be high → calibration curve hahaha!

Nope – if you mix small aliquots and analyze the usual volume the concen­tration will be arithmetic mean of the aliquots.

❝ One more thing, even the author wrote about the shortcoming of this method, tada! Cmax!

Yep. In the few studies where we applied the method it was not stated as a strict requirement in the protocol to stop the study. We had just one case where the method would suggest stopping based on the AUCP-ratio. The sponsor decided to proceed analyzing the subjects’ samples (“We have the budget allocated. Let’s give it a try at least.”) and the study passed…

❝ Not trying to bad mouth people but how could such article be worth publishing?

Let’s not start a discussion about the peer-review process of some (most?) journals.

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


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Science Quotes

Complete thread:

• Pooled Sample Analysis in WinNonlin BRN 2014-02-10 13:48 
  • Forget Pooled Sample Analysis Helmut 2014-02-10 14:27
    • Forget Pooled Sample Analysis BRN 2014-02-10 14:54
      • Forget Pooled Sample Analysis Helmut 2014-02-10 14:58
        • Forget Pooled Sample Analysis BRN 2014-02-10 15:11
        • Me too! jag009 2014-02-10 16:23
          • Crap… Helmut 2014-02-10 16:58
            • Crap… Ohlbe 2014-02-10 18:48
            • Crap^2 jag009 2014-02-10 20:27
              • Crap²Helmut 2014-02-11 13:45
                • Crap² ElMaestro 2014-02-11 14:41
                  • Crap² jag009 2014-02-11 17:27
                    • OT Helmut 2014-02-12 00:57
                      • OT ElMaestro 2014-02-12 14:03