Bioequivalence and Bioavailability Forum • Just thinking loud

Just thinking loud [Software]

posted by ElMaestro – Denmark, 2014-02-01 20:02 (4104 d 07:47 ago) – Posting: # 12309
Views: 27,855
(edited on 2014-02-02 01:27)

Thanks Yung-jin,

❝ ❝ "MSSubject(seq)-MSResidual" enter the game?

❝

❝ Should be this (as presented values in my previous post), I guess.

Here I am thinking loud, and usually nothing good results when I do it. But here goes:

By way of a typical anova (forget for a moment the case of imbalance and type III SS which is irrelevant anyway for the actual dataset example) we have:

SS_tot=SS_trt+SS_seq+SS_per+SS_subj+SS_res
where
MS_subj=SS_subj/(n-2) [n=total number of subjects counting both sequences]
and

MS_res= SS_res/(n-2).

I want to know what the color and taste of "MS_subj-MS_res" as prescribed above is:
MS_subj=SS_subj/(n-2)
or
MS_subj=(SS_tot-SS_trt-SS_seq-SS_per-SS_res)/(n-2)

Then
"MS_subj-MS_res" = (SS_tot-SS_trt-SS_seq-SS_per-SS_res)/(n-2) - SS_res/(n-2)
= (SS_tot-SS_trt-SS_seq-SS_per-2*SS_res)/(n-2)
This is truly a mindf%cker. My brain refuses to cooperate. I am experiencing the cerebral equivalent of a
Proton M rocket launch.
Actually, I am inclined to think there is something wrong with that subtraction in the first place.

—
Pass or fail!
ElMaestro

Complete thread:

How to calculate intersubject variability in PHX WinNonlin zan 2014-01-29 23:58
- Negative variance component Helmut 2014-01-30 01:16
  - Negative variance component zan 2014-01-30 18:11
  - Negative variance component zan 2014-01-31 00:16
    - Negative variance component ElMaestro 2014-01-31 08:20
    - Negative variance component yjlee168 2014-01-31 10:26
      - Example data set Helmut 2014-02-01 16:03
        
        Example data set yjlee168 2014-02-01 17:40
        
        PHX build 6.3.0.395 / 6.4.0.511 Helmut 2014-02-02 02:04
        
        PHX build 6.3.0.395 / 6.4.0.511 yjlee168 2014-02-02 07:54
    - Negative variance component ElMaestro 2014-02-01 16:31
      - Negative variance component yjlee168 2014-02-01 17:47
        
        Just thinking loudElMaestro 2014-02-01 19:02
        
        All models are wrong… Helmut 2014-02-02 02:31
        
        another book for linear model yjlee168 2014-02-02 08:07
      - References Helmut 2014-02-02 02:19
        
        References ElMaestro 2014-02-02 09:56
    - Negative variance component – Chow/Liu d_labes 2014-02-03 09:02
      - Negative variance component – Chow/Liu ElMaestro 2014-02-03 10:22
        
        Variance components – Proc mixed d_labes 2014-02-03 11:58
        
        Variance components – Proc mixed ElMaestro 2014-02-03 12:58
        
        Variance components – Proc mixed 90% CIs d_labes 2014-02-03 13:16
        Variance components – Proc mixed Helmut 2014-02-03 14:14
        
        FDA code for non-replicate crossover? d_labes 2014-02-03 15:54
        
        Proc GLM rulez Helmut 2014-02-03 16:16
        
        Variance components – Proc mixed yjlee168 2014-02-03 20:43
        
        NOBOUND Helmut 2014-02-03 22:08
      - lm() or lme() for 2x2x2 study design? yjlee168 2014-02-03 20:22
        
        lm() or lme() for 2x2x2 study design? ElMaestro 2014-02-03 22:11
        
        lm() or lme() for 2x2x2 study design? yjlee168 2014-02-04 13:09
        
        bear for 2x2x2 study with negative variance components yjlee168 2014-02-05 19:12