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RegisterSimcyp [Software]
posted by Helmut 
– Vienna, Austria, 2013-11-14 14:44 (4603 d 18:21 ago) – Posting: # 11886
Views: 10,826
Hi John,
Ana Henry.
Hhm.
Yep. A spin-off from the University of Sheffield, led by Geoffrey Tucker. Physiology-based PK/PD like GastroPlus. Contrary to PopPK/PD, which is “top-down” (empiric model based on fitting PK data including covariates) Simcyp follows a “bottom-up” approach. Based on the physicochemical properties of the drug and a huge database containing information about physiological parameters (absorption sites, organ blood-flows, metabolizing enzymes/transporters) and their dependencies on age, sex, ethnicity, disease states, etc. concentrations are predicted. Interesting stuff.
Simcyp was acquired by Certara about two years ago.
❝ I spoke with Ann (?)…
Ana Henry.
❝ … and she said a few lines were modified?
Hhm.
❝ Have you heard of a software called SYMCYP?
Yep. A spin-off from the University of Sheffield, led by Geoffrey Tucker. Physiology-based PK/PD like GastroPlus. Contrary to PopPK/PD, which is “top-down” (empiric model based on fitting PK data including covariates) Simcyp follows a “bottom-up” approach. Based on the physicochemical properties of the drug and a huge database containing information about physiological parameters (absorption sites, organ blood-flows, metabolizing enzymes/transporters) and their dependencies on age, sex, ethnicity, disease states, etc. concentrations are predicted. Interesting stuff.
Simcyp was acquired by Certara about two years ago.
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
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Complete thread:
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![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- u-diaeresis Helmut 2013-11-13 07:45
- u-diaeresis jag009 2013-11-13 22:58
- Off topic ElMaestro 2013-11-14 02:08
- SimcypHelmut 2013-11-14 13:44
- u-diaeresis jag009 2013-11-13 22:58
- u-diaeresis Helmut 2013-11-13 07:45
Ing. Helmut Schütz