Bioequivalence and Bioavailability Forum

Hi all,

Can someone run powerTOST in R to confirm the ISCV from the following:

1. CVfromCI(lower=0.8341, upper=0.9536, n=55, design="2x3x3", alpha=0.05, robust=TRUE)
2. CVfromCI(lower=0.7909, upper=0.9258, n=55, design="2x3x3", alpha=0.05, robust=TRUE)
3. CVfromCI(lower=0.7985, upper=0.9240, n=55, design="2x3x3", alpha=0.05, robust=TRUE)

My Results from R:
1. 0.2456493 or 24.56%
2. 0.2905871 or 29.06%
3. 0.2685729 or 26.86%

The result for 2 and 3 is a bit strange. The CIs are very similar and yet the ISCVs differ by 0.032 or in percentage = 3.2%?

Here are the T/R ratios:
1. 0.8918
2. 0.8557
3. 0.8589

I am running the latest PowerTOST....

Thanks
John