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RegisterCVintra: method [Software]
posted by Helmut 
– Vienna, Austria, 2013-08-02 16:24 (4705 d 21:18 ago) – Posting: # 11167
Views: 10,673
Hi Anu,
I strongly suggest to upgrade to Phoenix. WinNonlin 5.3 is not supported any more and buggy (to name a few: λz based on max. R²adj may include Cmax, nonparametric comparison of tmax always in lexical order of treatments, CI obtained from the BE wizard is wrong, whereas from LME is correct – requiring a workaround, …)
Inspectors might ask why you still use an outdated software – although the upgrade was free of charge for 3+ years.
Maybe. Since I installed my latest PHX-license WNL5.3 refuses to start, so I can’t check.
I would prefer the latter (aka adjusted mean). Only in a balanced study geometric mean = adjusted mean.
❝ WinNonlin version 5.3
I strongly suggest to upgrade to Phoenix. WinNonlin 5.3 is not supported any more and buggy (to name a few: λz based on max. R²adj may include Cmax, nonparametric comparison of tmax always in lexical order of treatments, CI obtained from the BE wizard is wrong, whereas from LME is correct – requiring a workaround, …)
Inspectors might ask why you still use an outdated software – although the upgrade was free of charge for 3+ years.
❝ Though treated the WinNonlin sheet as excel sheet and even without detaching it worked. Is it right?
Maybe. Since I installed my latest PHX-license WNL5.3 refuses to start, so I can’t check.
❝ Point estimate:
❝ T/R (Do we consider it as geometric mean ratio or Geometric least square mean ratio?)
I would prefer the latter (aka adjusted mean). Only in a balanced study geometric mean = adjusted mean.
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Helmut Schütz
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- Intrasubject Variance in WinNonlin Anu 2013-07-29 13:04
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- CVintra: method Helmut 2013-07-30 13:51
- CVintra: method Anu 2013-08-02 10:49
- CVintra: methodHelmut 2013-08-02 14:24
- CVintra: method BRN 2014-02-04 18:00
- Full or crippled model Helmut 2014-02-05 14:41
- Full or crippled model BRN 2014-02-06 08:38
- Widening the acceptance range Helmut 2014-02-06 14:42
- Full or crippled model BRN 2014-02-06 08:38
- Full or crippled model Helmut 2014-02-05 14:41
- CVintra: method Anu 2013-08-02 10:49
- CVintra: method Helmut 2013-07-30 13:51
Ing. Helmut Schütz