Bioequivalence and Bioavailability Forum

Hi Helmut,

Thank you very much for the reply.

❝ Which version?

WinNonlin version 5.3

❝ Was the setup for conventional ABE (= unscaled) or RSABE (= my implementation of FDA’s code)? In the latter case only CV_WR is meaningful and part of the output.

It was RSABE. Used the codes given in these paper to run the design in Phoenix

❝ I’m surprised that you got some output for a fully replicated design (I don’t).

My mistake sorry (Actually I had run the fully replicate taking 2 blocks at a time in a study, so that was there in my mind)

❝ • classical WinNonlin (≤5.3)

❝ — Run the Bioequivalence Wizard

❝ — Detach the result worksheet

❝ — Enter the formula in an empty cell, referring to the cell containing Var(Residual)

❝ — Refresh

Thanks . Though treated the WinNonlin sheet as excel sheet and even without detaching it worked. Is it right?

Have one more doubt, Can be a stupid one but still a qn please:
Point estimate:
T/R (Do we consider it as geometric mean ratio or Geometric least square mean ratio?)

Thanks & Regards
Anu Jaswal