Bioequivalence and Bioavailability Forum • Improbable

Improbable [Software]

posted by Helmut – Vienna, Austria, 2013-07-05 20:40 (4384 d 20:38 ago) – Posting: # 10949
Views: 12,348

Hi ElMaestro,

❝ […] if you are an egg-head with an IQ of 6 billion and qualified for a professorship at MIT…

At least chances for the former are somewhat low:

pnorm(6e9, mean=100, sd=15, lower.tail=FALSE)

❝ Science is really making progress these days.

Yep.

❝ Pharsight are you reading this? (Come on Simon, we know you are!)

BTW, to quote Senn and Grieve*

(2) Why would an investigator plan a trial with the object of proving equality of two formulations if the variances were believed different?
(4) Welch’s test is not universally accepted as being a valid approach to the problem of statistical inference for differences in means in the presence of heteroscedasticity.

Oh boy!

Senn S, Grieve AP. A Comment on Optimal Allocations for Bioequivalence Studies. Biometrics. 1999;55(4):1314–5.doi 10.1111/j.0006-341X.1999.01314.x

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

Parallel design [unequal variances] in Phoenix/WinNonlin Helmut 2013-07-04 20:22
- Parallel design [unequal variances] in Phoenix/WinNonlin ElMaestro 2013-07-04 21:16
  - Workaround Helmut 2013-07-04 22:13
    - 3-trt study? ElMaestro 2013-07-04 22:37
      - ؟ῳ ♠♣♥♦♪♫ѳ٭ Helmut 2013-07-04 23:08
  - Satterthwaite’s df in Phoenix/WinNonlin Helmut 2013-07-05 15:13
    - Satterthwaite’s df in Phoenix/WinNonlin ElMaestro 2013-07-05 17:08
      - Wikipedia, the free encyclopedia that anyone can edit. Helmut 2013-07-05 17:15
        
        Wikipedia, the free encyclopedia that anyone can edit. ElMaestro 2013-07-05 18:25
        
        ImprobableHelmut 2013-07-05 18:40