Bioequivalence and Bioavailability Forum • Phoenix settings for Potvin B/C

Phoenix settings for Potvin B/C [Software]

posted by Helmut – Vienna, Austria, 2013-03-29 12:46 (4407 d 06:34 ago) – Posting: # 10310
Views: 5,196

Hi Xipei!

In the Bioequivalence Options set Confidence Level 94.12. You will get (Potvin’s Example 2 after the second stage 2):

Output Data >

Average Bioequivalence

| CI_User_Lower | CI_User_Upper |

|     88.445196 |     116.37701 |

and (if Core Output selected in General Options):

Bioequivalence Statistics

User-Specified Confidence Level for CI's and Power = 94.1200

…

    Ratio(%Ref) =   101.4544



                      Classical                Westlake

    CI  80% = (   92.6916,  111.0456)  (   90.6629,  109.3371)

    CI  90% = (   90.1755,  114.1440)  (   87.7333,  112.2667)

    CI  95% = (   87.9420,  117.0430)  (   84.9996,  115.0004)

    CI User = (   88.4452,  116.3770)  (   85.6277,  114.3723)

    Average bioequivalence shown for confidence=94.12 and percent=20.0.

BTW, ElMaestro is right. If you already failed with the 90% CI you will fail with the 94.12% CI as well (smaller α → wider 1–2×α CI).

—
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Helmut Schütz

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Complete thread:

What software can change alpha to evaluate BE? wxp 2013-03-29 09:31
- What software can change alpha to evaluate BE? ElMaestro 2013-03-29 10:38
  - What software can change alpha to evaluate BE? wxp 2013-04-02 10:06
- What software can change alpha to evaluate BE? krishna 2013-03-29 11:32
  - What software can change alpha to evaluate BE? wxp 2013-04-02 10:03
- Phoenix settings for Potvin B/CHelmut 2013-03-29 11:46
  - Phoenix settings for Potvin B/C wxp 2013-04-02 10:20