Bioequivalence and Bioavailability Forum

Dear HS

❝ I’m afraid you have to give us more informations. Normally the half-life of drugs is too short to be influenced by an increasing number of cells (are you thinking about a tumor?).

Yes mainly for Tumor cell related metabolism!! and also for the drugs that get distributed in tissues for longer period of time.

❝ Exceptions are drugs with very long half-lives (let’s say, more than a week), or the patient is in true steady-state (again, I’m talking about weeks).

Yes! That is the main area of concern

❝ Some general remarks about modeling:

❝ • Get some books. Read them. Take a vacation. Read them again.

. I will love to do that!

❝ • If you really notice a change in clearance (e.g., in a multiple dose

❝   study trough values increase to a pseudo-equilibrium and subsequently

❝   decrease to the final steady state), try the following methods to model

❝   the changing clearance:

❝   • Add a lag-time.

Let me try this !!

❝   • Try a catenary model (additional hypothetical compartment before

❝     the central).

Yeah This might be the approach I should look for but what if I want to see and related the metabolism in the hypothetical compartment


Thanks for your suggestion!!
Let me read them first and clear my thoughts then I will be back!

Thanks a lot

Luv!!