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Registerf2 similarity factor metric [Dissolution / BCS / IVIVC]
Hi Oiinkie,
From USFDA-OGD recommendation, for Calcium acetate similarity factor may be applied to compare mean phosphate binding profiles. Whereas, in phosphate binding in-vitro study mean phosphate binding profile will be generated based on the initial phosphate concentration in the solution and not related to the time.
Hence, my doubt is whether we can apply f2 test to compare the concentration based mean profile without time involvement.
Hope it clears.
Regards
From USFDA-OGD recommendation, for Calcium acetate similarity factor may be applied to compare mean phosphate binding profiles. Whereas, in phosphate binding in-vitro study mean phosphate binding profile will be generated based on the initial phosphate concentration in the solution and not related to the time.
Hence, my doubt is whether we can apply f2 test to compare the concentration based mean profile without time involvement.
Hope it clears.
Regards
—
Sundar. M
Sundar. M
Complete thread:
- f2 similarity factor metric msmnainar 2013-01-30 07:20
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- Please clarify Helmut 2013-02-01 14:30
- f2 similarity factor metric jag009 2013-02-01 20:39
- f2 similarity factor metric msmnainar 2013-02-04 06:21
- f2 similarity factor metric Oiinkie 2013-02-04 17:14
- f2 similarity factor metricmsmnainar 2013-02-07 08:07
- f2 similarity factor metric Oiinkie 2013-02-04 17:14
- f2 similarity factor metric msmnainar 2013-02-04 06:21
Ing. Helmut Schütz