f2 similarity factor metric [Dissolution / BCS / IVIVC]

posted by Oiinkie  – The Netherlands, 2013-02-04 18:14 (4890 d 13:28 ago) – Posting: # 9964
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Dear Sundar,

❝ Am having initial and bound phosphate concentration for Test and Reference product, respectively as mentioned below. Kindly guide me can we do f2 calculation using this data, i.e. concentration in place of time.


It seems to me that you are trying to adopt the f2 calculation, which is specifically applied to compare dissolution profiles (concentration vs time data in a dissolution vessel), to a different concept. IMHO, you should find a different test to compare your products.

Regards,

Oiinkie

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