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Registerf2 similarity factor metric [Dissolution / BCS / IVIVC]
Hello All
Request your advise on the f2 similarity factor calculation,
Per below formula
f2 = 50*Log{1+1/N[SUM(Rt-Tt)2]}-0.5*100
where, Rt and Tt are the cumulative percentage dissolved at each of the selected n time points of the reference and test product, respectively.
Here, my doubt is in place of time, shall we use change in concentration where there is no time specific involvement.
Kindly clarify.
Thanks
Edit: Category changed. Helmut
Request your advise on the f2 similarity factor calculation,
Per below formula
f2 = 50*Log{1+1/N[SUM(Rt-Tt)2]}-0.5*100
where, Rt and Tt are the cumulative percentage dissolved at each of the selected n time points of the reference and test product, respectively.
Here, my doubt is in place of time, shall we use change in concentration where there is no time specific involvement.
Kindly clarify.
Thanks
Edit: Category changed. Helmut
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Sundar. M
Sundar. M
Complete thread:
- f2 similarity factor metricmsmnainar 2013-01-30 07:20
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Please clarify Helmut 2013-02-01 14:30
- f2 similarity factor metric jag009 2013-02-01 20:39
- f2 similarity factor metric msmnainar 2013-02-04 06:21
- f2 similarity factor metric Oiinkie 2013-02-04 17:14
- f2 similarity factor metric msmnainar 2013-02-07 08:07
- f2 similarity factor metric Oiinkie 2013-02-04 17:14
- f2 similarity factor metric msmnainar 2013-02-04 06:21
Ing. Helmut Schütz