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RegisterIVIVC question [Dissolution / BCS / IVIVC]
Hi
IR dose is normalised to unit dose/ 1 mg dose. Idea of having rapid release UIR is to get the pure distribution and eliminination charecteristics of drug without any interferance of absorption (true A, B alpha and Beta value) so if UIR is true then absorption wont go beyond the 100 %.
AUC of IR might be lower of SR formulation that happens but this does not prevent to develop IVIVC.
If drug is soluble then try taking fourth arm of IV formulation to get better IVIVC.
Regards
Chiku
IR dose is normalised to unit dose/ 1 mg dose. Idea of having rapid release UIR is to get the pure distribution and eliminination charecteristics of drug without any interferance of absorption (true A, B alpha and Beta value) so if UIR is true then absorption wont go beyond the 100 %.
AUC of IR might be lower of SR formulation that happens but this does not prevent to develop IVIVC.
If drug is soluble then try taking fourth arm of IV formulation to get better IVIVC.
Regards
Chiku
Complete thread:
- IVIVC question jag009 2012-08-16 20:18
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- IVIVC questionChiku 2012-08-22 08:04
Ing. Helmut Schütz