IVIVC Using "R" Package [Dissolution / BCS / IVIVC]

posted by Gajanan – 2011-01-31 08:53 (5630 d 12:06 ago) – Posting: # 6518
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I am trying to establish an IVIVC with R. In the IVIVC menu, I selected PK paremeters from literature and opted to enter PK parameters from references (option 2).In the data editor, I enetered, Ke and Vd values for 3 subjects and saved them. In step 3 (in vitro dissolution data and in vivo absorption data, I selected option 1, Input edit raw data from keyboard.Then I entered observed concentration and fraction dissolved data for 3 different PH and 3 formulations for 12 time points. In step 4, develop an IVIVC model: Model dependent method, I selected model dependent method, Which takes me to step 4, where an IVIVC model is developed. I have selected 1 compartment model Wagner Nelson method. I have entered dose value of extended release forms. Then the software asks me to 'Enter PK parameter data file name'.
At this step I dont know what I am supposed to know. I am new to IVIVC and request help on this

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