Bioequivalence and Bioavailability Forum

❝ Now the problem is with 150 mg. The dissolution of our test 150 mg formulation is not matching with the RLD 150 mg (both F1 and f2 is failing). But test formulation is dose propotional and it is perfectly matching the dissolution (getting f2 around 85 in b/t 150 mg Vs 300 mg test.

1. Doing the dissolution test, was it used the paddle method or the basket method? What rpm? 50, 100, 150?
2. What shape has the 150mg RLD tablet; has it the same shape as your 150mg formulation? is the 150mg RDL tablet larger that your formulation?

Regards
Irina