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RegisterIVIVC Using "R" Package [Dissolution / BCS / IVIVC]
Dear All,
I am new in this field and want to learn IVIVC concept using R package. My query is regarding computation of absorption constant, elimination and volume and distribution. In R, we need to specify the values of absorption constant, elimination and volume of distribution.
Can anybody tell me, based on what conditions we have to select these 3 values?
Actually, I have one pilot 2-way crossover bio-study data of ER oral formulation with 6 subjects which shows bioequivalence result (ratio & C.I. are between 80% to 125%) but when I input these data and its dissolution into R software to check IVIVC and its prediction error. It shows prediction error 37% and 41% for Cmax and AUC respectively. which is quite doubtful.
Thanks in advance.
Regards,
Tushar
I am new in this field and want to learn IVIVC concept using R package. My query is regarding computation of absorption constant, elimination and volume and distribution. In R, we need to specify the values of absorption constant, elimination and volume of distribution.
Can anybody tell me, based on what conditions we have to select these 3 values?
Actually, I have one pilot 2-way crossover bio-study data of ER oral formulation with 6 subjects which shows bioequivalence result (ratio & C.I. are between 80% to 125%) but when I input these data and its dissolution into R software to check IVIVC and its prediction error. It shows prediction error 37% and 41% for Cmax and AUC respectively. which is quite doubtful.
Thanks in advance.
Regards,
Tushar
Complete thread:
- IVIVC Using "R" PackageTushar.g 2010-05-20 06:54
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- IVIVC Using "R" Package yjlee168 2010-05-20 07:35
- IVIVC Using "R" Package Gajanan 2011-01-31 07:53
- IVIVC Using "R" Package yjlee168 2011-01-31 08:19
- IVIVC Using "R" Package Gajanan 2011-01-31 07:53
- IVIVC Using "R" Package yjlee168 2010-05-20 07:35
Ing. Helmut Schütz