Bioequivalence and Bioavailability Forum

Hi Daniel - sorry if this information comes to you late but I only just saw that no one had responded to your question and although I'm not an IVIVC expert...

❝ The article cite a rescaling procedure. How could I do it? Has someone already used this procedure for IVIVC?

To correlate deconvolved Fabs with Fdiss there are various correlation models that can be used. 3 are built into WinNonlin's IVIVC Wizard and you may find the third option would be the equation you'd like to implement:

Fabs = Fa*Fdiss(tscale*time-tshift)-Foffset

the "tscale" allows you to 'stretch' the Dissolution profile,
"tshift" is to account for a lag in absorption

You may of course modify a built-in model to account for some other factor. Hope this helps a little, you could also try watching one of Pharsight's free webinars on IVIVC that are hosted under events.

Simon