Bioequivalence and Bioavailability Forum • Prediction of Cmax

Prediction of Cmax [Dissolution / BCS / IVIVC]

posted by luvblooms – India, 2008-07-24 07:57 (6544 d 23:40 ago) – Posting: # 2074
Views: 8,376

dear Martin !

Thanks a lot for your precious comments

But i have certain doubts again
(sorry for that)

❝ (a) you can predict Cmax by using pharmacokinetic modeling by estimation of parameters based on your observed data and subsequently change the absorption rate based on your assumption

Can you please tell me how to do this using this example, that would be help me understanding the problem in a better way

❝ (b) your curve is simply shifted (on assumption of dose-proportionality) as using a different dose administered

We are using the same dose

❝ In case of a combination of a and b you may perform pharmaockinetic modeling by studying both parameters.

How can this be done???

Thanks for your help

Edit: Standard quotes restored. [Helmut]

—
~A happy Soul~

Complete thread:

Prediction of Cmax luvblooms 2008-07-22 06:43
- Prediction of Cmax martin 2008-07-23 10:24
  - Prediction of Cmaxluvblooms 2008-07-24 05:57
    - Prediction of Cmax martin 2008-07-24 09:56
      - Prediction of Cmax Helmut 2008-07-24 14:18
        
        Prediction of Cmax martin 2008-07-25 08:48