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RegisterPrediction of Cmax [Dissolution / BCS / IVIVC]
dear luvblooms !
as far as I understand your query you expect an increase release which may be due to
a) an increased absorption rate or
b) an increased fraction absorpt (fraction of dose that reaches systemic circulation)
in case of (a) you can predict Cmax by using pharmacokinetic modeling by estimation of parameters based on your observed data and subsequently change the absorption rate based on your assumption. in case of (b) your curve is simply shifted (on assumption of dose-proportionality) as using a different dose administered. In case of a combination of a and b you may perform pharmaockinetic modeling by studying both parameters.
hope this helps
martin
as far as I understand your query you expect an increase release which may be due to
a) an increased absorption rate or
b) an increased fraction absorpt (fraction of dose that reaches systemic circulation)
in case of (a) you can predict Cmax by using pharmacokinetic modeling by estimation of parameters based on your observed data and subsequently change the absorption rate based on your assumption. in case of (b) your curve is simply shifted (on assumption of dose-proportionality) as using a different dose administered. In case of a combination of a and b you may perform pharmaockinetic modeling by studying both parameters.
hope this helps
martin
Complete thread:
- Prediction of Cmax luvblooms 2008-07-22 06:43
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Prediction of Cmaxmartin 2008-07-23 10:24
- Prediction of Cmax luvblooms 2008-07-24 05:57
- Prediction of Cmax martin 2008-07-24 09:56
- Prediction of Cmax Helmut 2008-07-24 14:18
- Prediction of Cmax martin 2008-07-25 08:48
- Prediction of Cmax Helmut 2008-07-24 14:18
- Prediction of Cmax martin 2008-07-24 09:56
- Prediction of Cmax luvblooms 2008-07-24 05:57
- Prediction of Cmaxmartin 2008-07-23 10:24
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