Bioequivalence and Bioavailability Forum • Dissolution profie matching

Dissolution profie matching [Dissolution / BCS / IVIVC]

posted by Kiran – 2017-06-24 20:25 (3266 d 13:02 ago) – Posting: # 17500
Views: 11,451

Hello everyone?
I am developing a generic formulation with drug containing high soluble polymorphic form than the reference product and having difficulty in matching end stage of drug release.

Reference product is showing around 52 % whereas test product is showing 96% release at 90 minutes ??

Any suggestions???

Complete thread:

Dissolution profie matchingKiran 2017-06-24 18:25
- in vivo data before tweaking in vitro Helmut 2017-06-24 19:30
  - in vivo data before tweaking in vitro Kiran 2017-06-24 20:19
    - locally acting / diss. similarity mandatory Helmut 2017-06-25 12:48
      - locally acting / diss. similarity mandatory Kiran 2017-06-25 16:40
- Dissolution profie matching ElMaestro 2017-06-25 20:21
  - Dissolution profie matching Kiran 2017-06-26 05:11