ka vs. Cmax [Dissolution / BCS / IVIVC]

posted by mittyri  – Russia, 2017-06-10 16:59 (3291 d 11:32 ago) – Posting: # 17483
Views: 17,309

Hi Helmut & nobody,

Just got a chance to listen Laszlo Tothfalusi regarding this one

I'm not Nick H. and not Mats K. ever, but for me the problem is oversimplified there (Linked PKPD model with Concentration dependent hazard).

Since Ka is a key parameter (OK,ok, bioavailability) for bioequivalence, we need to get more suitable model for absorption of each drug (taking into account different rates for different parts of intestine, first-pass metabolism, distributed delay of absorption and so on)
PBPK guys are trying hard but it is still just endless investigations...

Even if all things are done, we got some tricky distribution of Ka among the population depending on formulation and many other things. Then we need to compare the distributions in some given populations...
Oh, sorry, looks like I was overdosed by popPK people :-D
—
Kind regards,
Mittyri

Complete thread:

UA Flag
Activity
 Admin contact
23,653 posts in 4,991 threads, 1,570 registered users;
155 visitors (0 registered, 155 guests [including 45 identified bots]).
Forum time: 04:32 CEST (Europe/Vienna)

The idea is to try and give all the information to help others
to judge the value of your contribution;
not just the information that leads to judgment
in one particular direction or another.    Richard Feynman

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5