increased solubility = different PK profile? [Dissolution / BCS / IVIVC]

posted by nobody – 2017-06-08 19:22 (2881 d 00:49 ago) – Posting: # 17464
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❝ Cmax is a lously PK metric. It is pretty insensitive to changes in the rate of absorption (papers by the two Lászlós two decades ago). Let’s say you will get the same AUC. Then the true rate of absorption (ka) can increase a lot until you will fall out of the BE-limits for Cmax.


Hmmm, did anybody try to establish ka as an alternative in BE? Would be fun to see some 100s of old BE-trials re-evaluated based on ka, I guess...
—
Kindest regards, nobody

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