Bioequivalence and Bioavailability Forum • increased solubility = different PK profile?

increased solubility = different PK profile? [Dissolution / BCS / IVIVC]

posted by nobody – 2017-06-08 19:22 (3293 d 02:55 ago) – Posting: # 17464
Views: 17,462

❝ C_max is a lously PK metric. It is pretty insensitive to changes in the rate of absorption (papers by the two Lászlós two decades ago). Let’s say you will get the same AUC. Then the true rate of absorption (k_a) can increase a lot until you will fall out of the BE-limits for C_max.

Hmmm, did anybody try to establish ka as an alternative in BE? Would be fun to see some 100s of old BE-trials re-evaluated based on ka, I guess...

—
Kindest regards, nobody

Complete thread:

increased solubility = different PK profile? Dr_Dan 2017-06-08 16:57
- increased solubility = different PK profile? nobody 2017-06-08 17:16
- increased solubility = different PK profile? Helmut 2017-06-08 17:18
  - increased solubility = different PK profile?nobody 2017-06-08 17:22
    - ka vs. Cmax Helmut 2017-06-09 14:35
      - ka vs. Cmax nobody 2017-06-09 16:27
      - ka vs. Cmax mittyri 2017-06-10 14:59
- increased solubility = different PK profile? ElMaestro 2017-06-08 17:24
  - increased solubility = different PK profile? Dr_Dan 2017-06-08 17:36
    - increased solubility = different PK profile? nobody 2017-06-08 17:43
    - increased solubility = different PK profile? Ohlbe 2017-06-08 18:23
      - increased solubility = different PK profile? nobody 2017-06-08 18:58
    - increased solubility = different PK profile? ElMaestro 2017-06-08 18:45
      - increased solubility = different PK profile? nobody 2017-06-08 18:57
        
        increased solubility = different PK profile? nobody 2017-06-09 09:38
- increased solubility = different PK profile? Kiran 2017-06-24 11:02