Log in
RegisterUsing f2 for compounds that never reach 85% dissolution [Dissolution / BCS / IVIVC]
❝ As the experts are apparently still on holiday 
I might start with some questions/remarks.
❝ Liposomes with doxorubicin (just wild guessing here 
) are no oral formulation afaik. Why would you do dissolution testing (simulation GI tract, normally)?
Wrong guess. :)
❝ The fraction of dose you get into solution pretty much depends on the media you use for your testing, in my opinion.
❝ So maybe some more details on the kind of products/projects your on might be helpful to get more response.
In this case it is for eye drops. So some medium that resembles tears would make sense, right? So I do think that comparing dissolution makes sense in this case, even though it is not the GI tract.
That still leaves the issue that we will not reach 85% dissolution in that medium. And I do think we should not keep many time points from the plateau phase.
Complete thread:
- Using f2 for compounds that never reach 85% dissolution wligtenberg 2017-01-03 15:48
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Using f2 for compounds that never reach 85% dissolution nobody 2017-01-03 19:19
- Using f2 for compounds that never reach 85% dissolutionwligtenberg 2017-01-04 10:46
- Using f2 for compounds that never reach 85% dissolution nobody 2017-01-04 11:52
- Using f2 for compounds that never reach 85% dissolutionwligtenberg 2017-01-04 10:46
- Using f2 for compounds that never reach 85% dissolution wligtenberg 2017-01-16 17:27
- Using f2 for compounds that never reach 85% dissolution Dr_Dan 2017-01-16 18:10
- Using f2 for compounds that never reach 85% dissolution wligtenberg 2017-01-17 09:00
- Using f2 for compounds that never reach 85% dissolution Dr_Dan 2017-01-16 18:10
- Using f2 for compounds that never reach 85% dissolution nobody 2017-01-03 19:19
Ing. Helmut Schütz