SAS/R code of MSD method for comparing dis­so­lution [Dissolution / BCS / IVIVC]

posted by Shuanghe  – Spain, 2014-12-24 12:09 (4204 d 22:12 ago) – Posting: # 14159
Views: 22,662

Hi arjunroy,

❝ Thank you

No problem.

for pooled variance, instead of using (st + sr) / 2, it's better to use:
sp = ((nt-1)*st + (nr-1)*sr)/(nt+nr-2)
This works regardless if nt = nr.

❝ Here is SAS IMLv9.1.3 log error for your perusal.

❝ ......


I use SAS 9.2 and the COV module defined as above worked. It seems version 9.1.3 didn't support operation for matrix with different dimensions therefore the line
d = m - m[:,];
gave error you had. Weird.

You can try the following code:

  START COV(m);             
    n = NROW(m);             
    d = m - REPEAT(m[:,],n,1);
    RETURN((d`*d)/(n-1));
  FINISH;

The REPEAT function will create a matrix with n rows with each row equal to the mean profile. Then the matrix will be of same dimensions for the subtraction to work.

You can report it back here if it works.
—
All the best,
Shuanghe

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