Log in
RegisterDissolution [Dissolution / BCS / IVIVC]
Guys and Girls,
A question... Suppose you have an IR drug product which is highly soluble but poor in permeability and has a Tmax of 8 hrs. Do you think slowing down the rate of in-vitro release will affect the overall PK?
Assume this scenario...
Under the same dissolution medium, assuming the reference is releasing no less than 80% at 30 mins, and your product is releasing no less than 80% at 60 mins. What do you think?
Thanks
John
A question... Suppose you have an IR drug product which is highly soluble but poor in permeability and has a Tmax of 8 hrs. Do you think slowing down the rate of in-vitro release will affect the overall PK?
Assume this scenario...
Under the same dissolution medium, assuming the reference is releasing no less than 80% at 30 mins, and your product is releasing no less than 80% at 60 mins. What do you think?
Thanks
John
Complete thread:
- Dissolutionjag009 2014-08-22 16:47
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Dissolution Dr_Dan 2014-08-22 19:27
- Dissolution jag009 2014-08-25 15:19
- Dissolution luvblooms 2014-08-26 06:41
- Dissolution jag009 2014-08-26 17:33
- Dissolution luvblooms 2014-08-28 08:21
- Dissolution Samaya B 2014-09-01 07:48
- Dissolution luvblooms 2014-09-01 14:09
- Dissolution Samaya B 2014-09-04 06:54
- Dissolution luvblooms 2014-09-01 14:09
- Dissolution Samaya B 2014-09-01 07:48
- Dissolution luvblooms 2014-08-28 08:21
- Dissolution jag009 2014-08-26 17:33
- Dissolution Dr_Dan 2014-08-22 19:27
Ing. Helmut Schütz