Bioequivalence and Bioavailability Forum • Dissolution

Dissolution [Dissolution / BCS / IVIVC]

posted by jag009 – NJ, 2014-08-22 18:47 (4326 d 05:02 ago) – Posting: # 13419
Views: 11,020

Guys and Girls,

A question... Suppose you have an IR drug product which is highly soluble but poor in permeability and has a Tmax of 8 hrs. Do you think slowing down the rate of in-vitro release will affect the overall PK?

Assume this scenario...
Under the same dissolution medium, assuming the reference is releasing no less than 80% at 30 mins, and your product is releasing no less than 80% at 60 mins. What do you think?

Thanks
John

Complete thread:

Dissolutionjag009 2014-08-22 16:47
- Dissolution Dr_Dan 2014-08-22 19:27
  - Dissolution jag009 2014-08-25 15:19
- Dissolution luvblooms 2014-08-26 06:41
  - Dissolution jag009 2014-08-26 17:33
    - Dissolution luvblooms 2014-08-28 08:21
      - Dissolution Samaya B 2014-09-01 07:48
        
        Dissolution luvblooms 2014-09-01 14:09
        
        Dissolution Samaya B 2014-09-04 06:54