Bioequivalence and Bioavailability Forum

HI JM,

sorry for not being specific, and thank yo for your post.

This is the background.

L1, L2, L3 refers to three formulation i am trying to develop (extended release), different concentration of the matrix.
L1 being the lowest concentration of the matrix, and in the dissolution study more drug was released within the first 30 minutes
L2 - medium concentration of the matrix
L3 - highest concentration of the matrix (less drug was released from the dissolution study)

Reference formulation: this data was extracted from a journal article (immediate release formulation).

its case 2, three different formulation trying to predict invivo pk profile.
We are expecting that L2 and L3 we will be having bio-availability issue and we are trying to prove this.

Please let me know if you need more information

Thank you

Mouli