Bioequivalence and Bioavailability Forum

Dear Sandeep,

Thank you for the reference link. quite useful. As I understand, you can solve 'z' first from Eq. (4) (as noted in literature, i.e., y = (z/V).t ) which is an integral equation. So you can simply use a linear regression method (forced to pass through zero) to solve Eq. (4) to obtain 'z' from the slope (= z/V). Then you solve Eq. (3) or (5) (as noted in literature; based on the model of your choice) as differential equations. According to literature, some variables (such as D, N, delta, rho and etc.) go to 'z' now. So I guess you don't have to worry about these variables. Is it to solve 'Cs' finally?

❝ I have exactly reproduced the equation (1) and (2) from the article.

❝ ..

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❝ Equation (1) is a differential equation and time variable on RHS will come after integration.

ok. It's my mistake. Sorry about this. They are all correct equations.