Bioequivalence and Bioavailability Forum

Modified Noyes-Whitney equation [Dissolution / BCS / IVIVC]

posted by sandeepdahiya – India, 2013-11-19 10:41 (4603 d 21:41 ago) – Posting: # 11908
Views: 9,282

Dear Yung-jin,

I have exactly reproduced the equation (1) and (2) from the article.
The article says that equation (2) is the integrated form of the equation (1) and the dissolution data is fitted to equation (2) to calculate the 'z value'.

❝ Modified Noyes-Whitney equation-

❝ dWt / dt = {D.T.N^1/3.W^2/3.(Xs-Wt)} / V.d.r^2/3

❝ = z.W^2/3.(Cs-C) -------- (1)

❝ y = (z/V).t ---------(2)

Equation (1) is a differential equation and time variable on RHS will come after integration.

❝ Did you miss the independent variable 'time' (i.e., 't') on the right-hand side of both equations? You cannot solve the DE in this case. Sorry I cannot access the article you mentioned previously. Also, the equation

You can access the first two pages of the article. Follow the below link and click on "Look Inside".
http://rd.springer.com/article/10.1023/A:1011071401306#

And fortunately all these equations are detailed in first two pages of the article.
Equation (3) and (4) of the article are the equations under discussion.

Complete thread:

• Fitting dissolution data to modified Noyes-Whitney Theory sandeepdahiya 2013-10-23 08:25 
  • Modified Noyes-Whitney equation sandeepdahiya 2013-10-23 10:44
    • Modified Noyes-Whitney equation yjlee168 2013-10-23 13:41
      • Modified Noyes-Whitney equation sandeepdahiya 2013-11-06 04:16
        • Modified Noyes-Whitney equation yjlee168 2013-11-06 06:11
          • Modified Noyes-Whitney equationsandeepdahiya 2013-11-19 09:41
            • Modified Noyes-Whitney equation yjlee168 2013-11-19 10:51
    • Modified Noyes-Whitney equation jag009 2013-10-23 16:45