Bioequivalence and Bioavailability Forum

Dear Sandeep,

Should Equation (2) be as dWt/dt = (z/V)*t? If yes, then it's a differential equation (DE).

BTW, in your previous post, you wrote:

❝ Modified Noyes-Whitney equation-

❝ dWt / dt = {D.T.N^1/3.W^2/3.(Xs-Wt)} / V.d.r^2/3

❝ = z.W^2/3.(Cs-C) -------- (1)

Did you miss the independent variable 'time' (i.e., 't') on the right-hand side of both equations? You cannot solve the DE in this case. Sorry I cannot access the article you mentioned previously. Also, the equation

dWt / dt = {D.T.N^1/3.W^2/3.(Xs-Wt)} / V.d.r^2/3

has 'Wt' (the dependent variable) on both sides. It apparently exhibits a saturation process for dissolution profile that sounds reasonable for "cumulated dissolved amount of drug at time 't'. However, there should be a 't' somewhere on the right-hand side of equation.

❝ Even i was not sure how the below equation was fitted. For sure it is not simple linear fitting.

OK, agree.
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❝ ❝ y = (z/V).t ---------(2)