Bioequivalence and Bioavailability Forum • Modified Noyes-Whitney equation

Modified Noyes-Whitney equation [Dissolution / BCS / IVIVC]

posted by sandeepdahiya – India, 2013-11-06 05:16 (4611 d 00:45 ago) – Posting: # 11862
Views: 9,120

Dear Yung-jin,

❝ I will suggest that you should look at R.

I will try R.

❝ I think 'z' here should be a secondary parameter, not a constant.

By constant i meant to say that it's value is constant for a given dissolution medium. and yes, V is constant.

Even i was not sure how the below equation was fitted. For sure it is not simple linear fitting.

❝ As the values of D, T, d, r, etc are difficult to have for every molecule, z-value can be obtained by fitting the dissolution data to equation (1) or the integrated form of equation (1) (below).

❝ ❝

❝ ❝ y = (z/V).t ---------(2)

❝

❝ I am not quite sure about this. If so, then big congratulation, your equation has been turned into a simple linear eq.

Thank you for your reply.

—
Sandeep

Complete thread:

Fitting dissolution data to modified Noyes-Whitney Theory sandeepdahiya 2013-10-23 08:25
- Modified Noyes-Whitney equation sandeepdahiya 2013-10-23 10:44
  - Modified Noyes-Whitney equation yjlee168 2013-10-23 13:41
    - Modified Noyes-Whitney equationsandeepdahiya 2013-11-06 04:16
      - Modified Noyes-Whitney equation yjlee168 2013-11-06 06:11
        
        Modified Noyes-Whitney equation sandeepdahiya 2013-11-19 09:41
        
        Modified Noyes-Whitney equation yjlee168 2013-11-19 10:51
  - Modified Noyes-Whitney equation jag009 2013-10-23 16:45