Bioequivalence and Bioavailability Forum

Fitting dissolution data to modified Noyes-Whitney Theory [Dissolution / BCS / IVIVC]

posted by sandeepdahiya – India, 2013-10-23 10:25 (4622 d 16:23 ago) – Posting: # 11729
Views: 10,716

I am trying to fit dissolution data to modified Noyes-Whitney Theory as mentioned in below article-
http://rd.springer.com/article/10.1023/A:1011071401306

I have tried to use the equation 3, 4 and 5 mentioned in the article, but am unable to calculate the z-value (I am very new to all this).

The available inputs are dissolution release profile and solubility.
Can anyone throw some light on how to calculate "z-value" by fitting these inputs to above mentioned equations?

Thanks in advance,
Sandeep.

Complete thread:

• Fitting dissolution data to modified Noyes-Whitney Theorysandeepdahiya 2013-10-23 08:25 
  • Modified Noyes-Whitney equation sandeepdahiya 2013-10-23 10:44
    • Modified Noyes-Whitney equation yjlee168 2013-10-23 13:41
      • Modified Noyes-Whitney equation sandeepdahiya 2013-11-06 04:16
        • Modified Noyes-Whitney equation yjlee168 2013-11-06 06:11
          • Modified Noyes-Whitney equation sandeepdahiya 2013-11-19 09:41
            • Modified Noyes-Whitney equation yjlee168 2013-11-19 10:51
    • Modified Noyes-Whitney equation jag009 2013-10-23 16:45