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Hi,
Correct.
Additional comments:
Hope this helps.
John
❝ Since %PE for AUC_last is <10% and not for Cmax.
❝ Does that mean IVIVC is not established?
Correct.
Additional comments:
- An IVIVC should have 3 formulations (it takes 3 pts to do a correlation, 3=fast, target (medium), slow formulations). You only have 2.
- Is your formulation an IR? If so, it maybe difficult to achieve IVIVC.
- Depending on the solubility and permeability of the drug, it might not be possible to do an IVIVC (Refer to BCS classification).
Hope this helps.
John
Complete thread:
- WinNonlin IVIVC Toolkit Anu 2013-07-26 12:33
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- WinNonlin IVIVC Toolkitjag009 2013-07-26 15:31
- WinNonlin IVIVC Toolkit Anu 2013-07-29 12:21
- WinNonlin IVIVC Toolkit jag009 2013-07-30 16:13
- WinNonlin IVIVC Toolkit Anu 2013-08-02 08:33
- WinNonlin IVIVC Toolkit jag009 2013-07-30 16:13
- WinNonlin IVIVC Toolkit Anu 2013-07-29 12:21
- WinNonlin IVIVC Toolkitjag009 2013-07-26 15:31
Ing. Helmut Schütz