Bioequivalence and Bioavailability Forum

bootstrap f2 in R [Dissolution / BCS / IVIVC]

posted by Shuanghe  – Spain, 2013-06-14 17:13 (4327 d 20:23 ago) – Posting: # 10795
Views: 28,948

Thanks a lot Detlew!

❝ If you (or others) are interested, send me a mail.

I've sent an email to you by the Forum.

❝ But as Helmut always states "Take the code with a grain of salt". It comes without any warranty not to damage your computer .

I'll take it with "much more than one grain of salt", I promise.

by the way, what do you think of the following step for SAS:

1. PROC SURVEYSELECT to generate 1000 dataset with 12T and 12R each.
2. obtain mean T and R at each time point.
3. apply f2 criteria of >= 3 points, no > 1 point with >85% dissolution etc
4. calculate f2
5. 5% percentile as lower limit of 90% confidence interval.

Complete thread:

• FDA prefer bootstrap f2 to MSD method Shuanghe 2013-06-14 10:55 
  • bootstrap f2 in R d_labes 2013-06-14 13:48
    • Off-topic Helmut 2013-06-14 14:30
    • bootstrap f2 in RShuanghe 2013-06-14 15:13
      • bootstrap f2 in SAS d_labes 2013-06-14 15:55
  • FDA prefer bootstrap f2 to MSD method yjlee168 2013-06-15 22:17
    • "FDA acceptable" software or code to calculate bootstrap F2? sameep 2015-01-07 06:08
  • FDA prefer bootstrap f2 to MSD method AngusMcLean 2013-06-18 16:06
    • R-package for bootstrapping f2? d_labes 2013-06-19 08:20
      • R-package for bootstrapping f2? AngusMcLean 2013-06-19 21:51
        • Bootstrapping f2 in Pascal d_labes 2013-06-20 08:18
          • source code is available? ElMaestro 2013-06-20 12:45
            • Yes, source code is available yjlee168 2013-06-20 13:21
          • Bootstrapping f2 in Pascal AngusMcLean 2013-06-20 15:29
          • Bootstrapping f2 in Pascal AngusMcLean 2013-06-22 00:47
            • OT Helmut 2013-06-22 02:57
              • OT AngusMcLean 2013-06-22 15:57