Bigamist [Power / Sample Size]

posted by d_labes  – Berlin, Germany, 2013-02-09 19:11 (4886 d 13:13 ago) – Posting: # 9996
Views: 12,882

Dear Helmut!

❝ Do you want to marry me? The community will love you for that!


They would call me "Bigamist" and send me to prison in many countries. And I think my spouse wouldn't be very amused if I convert to a Mussulmán in my old days :-D.

But anyhow: Thanks for the flowers.

❝ Opens even the door for two-stage simulations where the intermediate power/sample size was the actual show-stopper.


I'm not quite sure if you are right here. In simulating 2-stage adaptive designs the power/sample size steps may contribute considerably to the computation times. Thus they may stay the show-stopper even if we can push on the calculations of stage 1/stage 2 BE by the ideas behind power.scABEL() or behind the code inthis post.
But lets see ...

2-stage design combined with RSABE will have another drawback: Where is the point for simulations which represents alpha :confused:? Simply GMR=1.25 (or whatever BE limit applies) surely not.
Eventually power.scABEL() will help to explore.

Regards,

Detlew

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