Bioequivalence and Bioavailability Forum • CVinter

CVinter > CVintra! [Power / Sample Size]

posted by krishna – India, 2012-11-30 06:46 (4949 d 17:00 ago) – Posting: # 9639
Views: 10,764

Hi Helmut,

❝ Sequence+Subject(Sequence)+Formulation+Period.

❝

❝ To do this, use the following steps:

❝ 1. Start BE Wizard.

❝ 2. Specify reference formulation → Next

❝ 3. Specify dependent variable, e.g. Cmax → Next

❝ 4. Click Delete Random to remove Subject(Sequence) component → Back

❝ 5. Add Subject(Sequence) to the Fixed effects model as shown above

❝ 6. Click Calculate

After doing above correction in WinNonlin, I am observing slight increase in SE as a consequence CI is widening slightly. Also, p-value for sequence is working against 'Residual Error' as error term rater than 'Subject(sequence)' term. How this problem can be fixed and what is the reason for increment of SE ?

Thanks,

Krishna.

Complete thread:

can inter sub CV% > intra sub CV%? stat_be 2007-09-27 13:15
- CVinter > CVintra! Helmut 2007-09-27 13:34
  - CVinter > CVintra! stat_be 2007-10-03 07:35
    - CVinter > CVintra! Ohlbe 2007-10-03 10:04
      - ANOVA not for Tmax! Helmut 2007-10-03 15:02
    - CVinter > CVintra! Helmut 2007-10-15 16:15
      - CVinter > CVintra! stat_be 2007-10-16 12:19
        
        CVinter > CVintra! Helmut 2007-10-16 13:15
      - CVinter > CVintra!krishna 2012-11-30 05:46
        
        WinNonlin random vs. fixed model Helmut 2012-11-30 13:54