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RegisterTotal CV from Literature [Power / Sample Size]
posted by Helmut 
– Vienna, Austria, 2012-02-16 14:11 (5236 d 23:05 ago) – Posting: # 8130
Views: 4,250
Dear Chiku!
Yes, you can. For one of the APIs I have worked on the CVs were pretty reproducible in 10/20/30/40/60 mg studies (linear PK). Since CVtotal includes between-subject variability note that you have to keep the inclusion/exclusion criteria in the parallel study at least as stringent as in the cross-over. Don’t forget to add a safety margin.
❝ […] we have ANOVA for a Cross over study. This study was for the strength of 10 mg. Can we use total %CV obtained from this study to design a parallel study for 20 mg (there's pharmacokinetics linearity between 10 and 20 mg). I think we can use it because CV is a relative measure of variability, it is not absolute.
Yes, you can. For one of the APIs I have worked on the CVs were pretty reproducible in 10/20/30/40/60 mg studies (linear PK). Since CVtotal includes between-subject variability note that you have to keep the inclusion/exclusion criteria in the parallel study at least as stringent as in the cross-over. Don’t forget to add a safety margin.
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Helmut Schütz
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- Total CV from Literature Chiku 2012-02-15 06:33
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Total CV from Literature Helmut 2012-02-15 14:19
- Total CV from Literature Chiku 2012-02-16 07:23
- Total CV from LiteratureHelmut 2012-02-16 13:11
- Total CV from Literature Chiku 2012-02-16 07:23
- Total CV from Literature Helmut 2012-02-15 14:19
Ing. Helmut Schütz