Bioequivalence and Bioavailability Forum

Sample size calculations: SAS vs PowerTOST/FARTSSIE [Power / Sample Size]

posted by Helmut  – Vienna, Austria, 2011-12-06 15:49 (5320 d 04:18 ago) – Posting: # 7761
Views: 11,561

Dear Oiinkie!

❝ At the moment, we are having a discussion with a CRO on sample size calculations and which software to use. I have recommended PowerTOST and FARTSSIE, but they want to stick with SAS (because “they have always used it” ).

That’s the type of argument I definitely like the most. In line with “We have used bloodletting for 2000 years – can’t be wrong.” Quackery!

❝ This would be fine with me as long as all calculations match, but they do not.

Shouldn’t be such a big difference? See here and there.

❝ How can I convince the CRO to also look into the possibilities of using other software besides SAS and that sample sizes calculated with SAS are not (always) the "correct" approximations?

Well, you are the boss.

❝ And, what to do with (how to approach) different outcomes (SAS vs others)?

Stick with the best. @Detlew: Is Proc Power still ‘experimental’ and/or are Owen’s functions documented in the meantime?

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

• Sample size calculations: SAS vs PowerTOST/FARTSSIE Oiinkie 2011-12-06 14:30 
  • Sample size calculations: SAS vs PowerTOST/FARTSSIEHelmut 2011-12-06 14:49
    • Sample size calculations: SAS vs PowerTOST/FARTSSIE Oiinkie 2011-12-07 15:57
      • The power not to know vs PowerTOST/FARTSSIE/... d_labes 2011-12-12 15:38
        • Paired designs not that uncommon Helmut 2011-12-12 17:05
          • Paired designs not that uncommon ElMaestro 2011-12-13 17:04
            • Off topic: software validation Helmut 2011-12-13 18:10
              • Off topic: software validation ElMaestro 2011-12-13 20:30
                • Off topic: software validation Helmut 2011-12-14 14:14
              • Discovery of Owen's Q in SAS d_labes 2011-12-14 15:34
        • Paired designs in PowerTOST 0.9-0 Helmut 2011-12-19 20:05