Sample size calculations: SAS vs PowerTOST/FARTSSIE [Power / Sample Size]

posted by Oiinkie  – The Netherlands, 2011-12-06 15:30 (5320 d 07:06 ago) – Posting: # 7760
Views: 12,843

Dear all,

As also mentioned in other threads in the forum, sample sizes (and power) calculated with SAS are frequently different than calculated with (freely available) software, e.g. PowerTOST for R and FARTSSIE for Excel, specialized for (2x2) BE (which I definitely trust more; SAS is like a black box).

At the moment, we are having a discussion with a CRO on sample size calculations and which software to use. I have recommended PowerTOST and FARTSSIE, but they want to stick with SAS (because “they have always used it” :confused:). This would be fine with me as long as all calculations match, but they do not.

How can I convince the CRO to also look into the possibilities of using other software besides SAS and that sample sizes calculated with SAS are not (always) the "correct" approximations? And, what to do with (how to approach) different outcomes (SAS vs others)?

Thanks in advance!

Best regards,

Oiinkie

Regards,

Oiinkie

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