Bioequivalence and Bioavailability Forum • Sample Size and CV for Replicate Design

Sample Size and CV for Replicate Design [Power / Sample Size]

posted by Jamesmartinn – 2011-11-27 00:52 (5318 d 16:01 ago) – Posting: # 7730
Views: 11,053

Dear EM,

Thank you for your reply. I downloaded the package and indeed I see the 2x2x4 design is supported. However, given the information I have available and my ultimate goal, I'm not sure how to specify what I need. I see targetpower=0.80 and alpha=0.05, as well as a few other arguments such as CV and theta. Do I have enough information in what I posted in the initial post to solve my problem using PowerTOST? I should mention I've never used the CV metric before, and I don't see an argument to specify both the 0.35 and 0.30 numbers. Are these values some how related to the 'theta' values that I'm also asked to specify?

Thank you so much.

Edit: Full quote removed. Please delete anything from the text of the original poster which is not necessary in understanding your answer; see also this post! [Helmut]

Complete thread:

Sample Size and CV for Replicate Design Jamesmartinn 2011-11-26 20:22
- Sample Size and CV for Replicate Design ElMaestro 2011-11-26 22:38
  - Sample Size and CV for Replicate DesignJamesmartinn 2011-11-26 23:52
    - Sample Size and CV for Replicate Design ElMaestro 2011-11-27 00:43
      - Sample Size and CV for Replicate Design Jamesmartinn 2011-11-27 00:50
        
        Sample Size and CV for Replicate Design ElMaestro 2011-11-27 01:24
        
        Sample Size and CV for Replicate Design Jamesmartinn 2011-11-27 01:50
        
        Strange questions… Helmut 2011-11-27 04:47
        
        Strange questions… Jamesmartinn 2011-11-27 14:43
        
        Misusing PowerTOST for superiority? Helmut 2011-11-27 17:46
        
        Strange questions… ElMaestro 2011-11-27 15:14
        
        Strange questions… Helmut 2011-11-27 18:07